ORIGINAL RESEARCH
Cellular and metabolic basis for the ichthyotic phenotype in NIPAL4 (ichthyin)-deficient canines. Mauldin, EA., Crumrine, D., Casal, ML., Jeong, S., Opalka, L., Vavrova, K., Uchida, Y., Park, K., Craiglow, B., Choate, KA., Shin, K-O., Lee, Y-M., Grove, GL., Wakefield, JS., Khnykin, D., Elias, PM. Amer J of Pathology. In Press March 2018.
Skin care products can aggravate epidermal functions: studies in a murine model suggest a pathogenic role in sensitive skin. Li, Z., Hi, L., Elias, PM., Man, MQ. Contact Dermatitis. 78(2): 151-158, 2018.
Topical 11-hydroxysteroid dehydrogenase type 1 inhibition corrects cutaneous features of systemic glucocorticoid excess in female mice. Tiganescu, A., Hupe, M., Uchida, Y., Mauro, T., Elias, PM., Holleran, WM. Endocrinology. 159(1) 547-556, 2018.
Did hairlessness stimulate an increase in hominin brain size? Insights from the cutaneous neurosensory interface and comparative vertebrate morphology. Denda, M., Menon, G., Elias, PM. Anthropology, 6(1): 1-6, 2018.
PNPLA1 deficiency in mice and humans leads to a defect in the synthesis of omega-O-acylceramides. Grond, S., Eichmann, TO., Dubrac, S., Kolb, D., Schmuth, M., Fischer, J., Crumrine, D., Elias, PM, Haemmerle, G., Zechner, R., Lass, A., Radner, FP. J Invest Dermatol. 137(2): 394-403, 2017.
Alterations in epidermal eicosanoid metabolism contribute to inflammation and impaired late differentiation in FLG-mutated AD. Blunder, S., Rühl, R., Moosbrugger-Martinz, V., Krimmel, C., Geisler, A, Crumrine, D, Elias, PM., Gruber, R, Schmuth, M, Dubrac, S. J Invest Dermatol. 137(3): 706-715, 2017.
Skin barrier development depends on CGI-58 protein expression during late-stage keratinocyte differentiation. Grond, S., Radner, F., Eichmann, T., Kolb, D., Grabner, G., Wolinski, H., Gruber, R., Hofer, P., Heier, C., Schauer, S., Ruelicke, T., Hoefler, G., Schmuth, M., Elias, PM, Lass, A., Zechner, R., Haemmerle, G. J Invest Dermatol. 137(2):403-413, 2017.
Epidermal dysfunction leads to an age-associated increase in levels of serum inflammatory cytokines. Hu, L., Mauro, TM., Dang, E., Man, G., Zhang, J., Lee, D. Wang, G. Feingold, K.R., Elias, PM., Man, MQ. J Invest Dermatol. J Invest Dermatol. 137(6): 1277-1285, 2017.
Filaggrin loss-of-function mutations, atopic dermatitis and risk of actinic keratosis; results from two cross-sectional studies. Anderson, Y., Egeberg, A., Balslev, E. Jorgensen, Ch., Szecsi, P., Stender, S., Kaae, J., Linneberg, A., Gislason, Skov, L., Elias, PM., Thyssen, JP. J Eur Acad Dermatol Venereol. 31(6): 1038-1043, 2017.
Embryonic AP1 transcription factor deficiency causes a collodion baby-like phenotype. Young CA, Eckert RL, Adhikary G, Crumrine D, Elias PM, Blumenberg M, Rorke EA, J Invest Dermatol. 137(9): 1868-1877, 2017.
Topical histamine stimulates repigmentation of nonsegmental vitiligo by a receptor-dependent mechanism. Liu, J., Xu, Y., Lin, TK., Lv, C., Elias, PM., Man, M-Q. Skin Pharmacol Physiol 30(3): 139-145, 2017.
Dominant de novo DSP mutations cause erythrokeratodermia-cardiomyopathy syndrome. Boyden, LM., Kam. CY., Hernandez-Martin, A., Zhou, J., Craiglow, BG., Sidbury, R., Mathes, EF., Maguiness, SM., Crumrine, DA., Williams, ML., Hu, R., Lifton, R.P., Elias, PM., Green, KJ., Choate, KA. Hum Mol Genet. 25(2): 348-57, 2016.
ER stress stimulates production of the key antimicrobial peptide, cathelicidin, by forming a novel intracellular S1P signaling complex. Park, K., Ikushiro, H., Seo, HS., Shin, K-O., Kim, YI., Kim, JY., Lee, Y-M., Holleran, WR., Elias, PM., Uchida, Y. PNAS 113(10): E1334-42, 2016.
Combined benefits of a PAR2 inhibitor and stratum corneum acidification for murine atopic dermatitis. Sakai, T., Hatano, Y., Matsuda-Hirose, H., Zhang, W., Takahashi, D., Jeong, SK, Elias, PM., Fujiwara, S. J Invest. Dermatol. 136(2): 538-541, 2016.
Commonly employed African neonatal skin care products compromise epidermal function in mice. Man, M.Q., Sun, R., Man, G., Lee, D., Hill, Z., Elias, PM. Ped Dermatol. 33(5): 493-500, 2016.
Defects in stratum corneum desquamation are the predominate effect of impaired Abca12 function in a novel mouse model of harlequin ichthyosis. Zhang, L, Ferreyros, M., Feng, W., Hupe, M., Crumrine, D., Chen, J., Elias, PM., Holleran, WM., Niswander, L., Hohl, D., Williams, T., Torchia, EC., Roop, DR. PLoS ONE 11(8): e0161465, 2016.
Heavy cigarette smokers in a Chinese population display a compromised permeability barrier. Shujun, X., Ye, L., Man, G., Lv, C., Elias, PM., Man, M-Q. BioMed Res Intl. Online Publication, 2016.
Lowered humidity produces human epidermal equivalents with enhanced barrier properties. Sun, R., Celli, A., Crumrine, D., Hupe, M., Adame, L., Pennypacker, S., Park, K., Uchida, Y., Feingold, K. R., Elias, P. M., Ilic, D. and Mauro, T. M. Tissue Eng Part C Methods. 21(1): 15-22, 2015.
Cellular basis for secondary infections and impaired desquamation in certain inherited ichthyoses. Chan, A., Godoy-Gijon, E., Nuno-Gonzalez, A., Crumrine, D. Hupe, M., Choi, EH., Gruber, R., Williams, ML., Choate, K., Fleckman, PH., Elias, PM. JAMA Derm. 151(3): 285-92, 2015.
Structural and biochemical changes underlying a keratoderma-like phenotype in mice lacking suprabasal AP1 transcription factor function. Rorke, E., Adhikary, G., Young, C., Rice, R., Elias, P.M., Crumrine, D., Meyer, J., Blumenberg, M., Eckert, R.L. Cell Death and Disease. Online Publication 2015.
Frequent somatic reversion of KRT1 mutations in ichthyosis with confetti. Choate, KA., Lu Y, Zhou J., Elias, PM,. Zaidi, S., Paller, AS,. Farhi, A., Nelson-Williams, C., Crumrine, D., Milstone, LM., and Lifton,RP. J Clin Invest. 125(4): 1703-7, 2015.
Topical hesperidin enhances epidermal function in an aged murine model. Man, G., Mauro, TM., Zhai, Y., Kim, P., Cheung, C., Hupe, M., Crumrine, D., Elias, PM., Man, M-Q. J Invest Dermatol. 135(4): 1184-87, 2015.
Sebaceous gland, hair shaft, and epidermal barrier abnormalities in keratosis pilaris with and without filaggrin deficiency. Gruber, R. Sugarman, J. L., Crumrine, D., Hupe, M., Mauro, T.M., Mauldin, E.A., Thyssen, J.P., Brandner, J.M., Hennies, H-C., Schmuth, M., Elias, P.M. Am J Pathol.185(4): 1012-21, 2015.
UVB induces epidermal 11-hydroxysteroid dehydrogenase type 1 activity in vivo. Tiganescu, A., Hupe, M., Jiang, Y., Celli, A., Uchida, Y., Mauro, TM., Bikle, D., Elias, PM., Holleran, WM. Exper Dermatol. 24(5): 370-6, 2015. https://www.ncbi.nlm.nih.gov/pubmed/25739654
Sphingosine kinase 1 activation enhances epidermal innate immunity through sphingosine-1-phosphate stimulation of cathelicidin production. Jeong, S.K., Kim, Y.I., Shin, K-O., Kim, B-W., Lee, S.H., Jeong, E.J., Kim, H.J., Lee, Y-M., Mauro, T.M., Elias, P.M., Uchida, Y., Park, K. J Dermatol Sci. 79(3): 229-34, 2015.
Severe dermatitis, multiple allergies and metabolic (SAM) syndrome caused by a novel mutation in the N-terminal plakin domain of desmoplakin. McAleer, MA., Pohler, E., Smith, FJ., Wilson, NJ., Cole, C., MacGowan, S., Koetsier, JL., Godsel, LM., Harmon, RM., Gruber, R., Crumrine, D., Elias, PM., McDermott, M., Butler, K., Broderick, A., Sarig, O., Sprecher, E., Green, KJ., McLean, WH., Irvine, AD. J Allergy Clin Immunol. 136(5): 1268-76, 2015
Increased glucocorticoid activation during mouse skin wound healing. Tiganescu, A., Hupe, M., Uchida, Y., Mauro, TM., Elias, PM., Holleran, WM. J Endocrin. 221(1): 51-61, March 2014.
10-year publication trends in dermatology in mainland China. Xin, S., Mauro, J.A., Mauro, T.M., Elias, PM., Man. M.Q. Intl J Dermatol. 53(10): e438-42, 2014.
Basis for enhanced barrier function of pigmented skin. Man, MQ., Lin, TK., Santiago, JL., Celli, A., Zhong, L., Huang, Z-M., Roelandt, T., Hupe, M., Sundberg, J., Silva, K., Crumrine, D., Hu, L., Martin-Ezquerra, G., Trullas, C., Sun, R., Wakefield, J., Wei, M., Feingold, KR., Mauro, TM., Elias, PM. J Invest Dermatol. 134(9): 2,399-2,407, 2014.
Abnormal function in uninvolved skin is consistent with an epidermal pathogenesis of psoriasis. Ye, L., Lv, C., Man, G., Song, S., Elias, PM., Man, MQ. J Invest Dermatol. 134(11): 2843-2846, 2014.
Ultrastructure of skin from Refsum disease with emphasis on epidermal lamellar bodies and stratum corneum barrier lipid organization. Menon, G.K., Orso, E., Aslanidis, C., Crumrine, D., Schmitz, G. Elias, PM. Arch Dermatol Res. 306(8): 731-7,2014.
The dietary ingredient, genistein, stimulates cathelicidin antimicrobial peptide expression through a novel S1P-dependent mechanism. Park, K., Kim. Y-I., Shin, K-O., Seo, HS., Kim, JY., Mann, T., Oda, Y., Lee, Y-M., Holleran, WM., Elias, PM., Uchida, Y. J Nutr Biochem. 25(7):734-740, 2014.
Paradoxical benefits of psychological stress in inflammatory dermatoses models are glucocorticoid-mediated. Lin, TK., Man, MQ., Santiago, J-L., Hupe, M., Martin-Ezquerra, G., Youm, J-K., Zhai, T., Trullas, C., Feingold, KR., Elias, PM. J Invest Dermatol. 134(12): 2890-2897, 2014.
Topical hesperidin prevents glucocorticoid-induced abnormalities in epidermal barrier function in murine skin. Man, G., Mauro, T.M., Kim, PL., Hupe, M., Zhai, Y., Sun, R., Crumrine, D., Cheung, C. Nuno-Gonzalez, A., Elias, PM., Man, M-Q. Exp. Dermatol. 23(9): 645-651, 2014.
An ER stress-initiated sphingolipid metabolite, ceramide-1-phosphate, regulates epithelial innate immunity by stimulating ?-defensin production. Kim, Y-I., Park, K., Kim, JY., Seo, HS., Shin, K-O., Lee, Y-M., Holleran, WM., Elias, PM., Uchida, Y. Mol Cell Biol. 34(24):4368-78, 2014.
Comparison of publication trends in dermatology among Japan, Mainland China and South Korea. Man, H., Xin, S., Bi, W., Lv, C., Mauro, TM., Elias, PM., Man, M-Q. BMC Dermatology. 14(1): 1-6, 2014.
Abnormal function in uninvolved skin is consistent with an epidermal pathogenesis of psoriasis. Ye, L, Lv, C, Man, G, Song, S, Elias, PM, Man, M-Q. J Invest Dermatol. 134, 2843-2846 (2014).
Evidence that loss-of-function filaggrin mutations evolved in northern Europeans to favor intracutaneous vitamin D3 production. Thyssen, JP, Bikle, DD, Elias, PM. Evol Biol. 41, 388-396 (2014).
Ichthyosis vulgaris – the filaggrin mutation disease. Thyssen, JP, Godoy-Gijon, E, Elias, PM. Brit J Dermatol. 168(6): 1155-1166 (2013).
Comment on ‘Does a history of eczema predict a future basal cell carcinoma?’ Elias, PM, Williams, ML. J Invest Dermatol. 133(6): 1676-1677 (2013).
Re-appraisal of current theories for the development and loss of epidermal pigmentation in hominins and modern humans. Elias, PM, Williams, ML. J Human Evol. 64(6): 687-692 (2013).
Topical apigenin improves epidermal permeability barrier homeostasis in normal murine skin by divergent mechanisms. Hou, M., Sun, R., Hupe, M., Kim, P., Park, K., Crumrine, D., Lin, T.K., Santiago, J.L., Mauro, T.M., Elias, P.M., Man, M.Q. Exp. Derm. 22(3): 210-215 (2013).
A novel role of a lipid species, sphingosine-1-phosphate, in epithelial innate immunity. Park, K, Elias, PM, Shin, K-O, Borkowski, A, Lee, Y-M, Gallo, R, Saba, J, Holleran, WM, Uchida, Y. Mol Cell Biol. 33(4):752-762 (2013).
Ceramides stimulate caspase-14 expression in human keratinocytes. Jiang, YJ, Kim, P, Lu, YF, Elias, PM, Bikle, DD, Grunfeld, C, Feingold, KR. Exp. Derm. 22(2): 113-118 (2013).
The Th2 cytokine, interleukin-4, abrogates the cohesion of normal stratum corneum in mice: implications for pathogenesis of atopic dermatitis. Hatano, Y, Adachi, Y, Elias, PM, Crumrine, D, Sakai, T, Kurahashi, R, Katagire, K, Fijuwara, S. Exper.Dermatol. 22(1):30-5 (2013).Histamine suppresses epidermal keratinocyte differentiation and impairs skin barrier function in a human skin model. Gschwandtner, M, Mildner, M, Mlitz, V, Gruber, F, Eckhart, L, Werfel, T, Gutzmer, R, Elias, PM, Tschachler, E. Euro J Allergy & Clin Immun. 68(1): 37-47 (2013).
Topical antihistamines display potent anti-inflammatory activity linked in part to enhanced permeability barrier function. Lin, TK, Man, MQ, Santiago, JL, Park, K, Roelandt, T, Oda, Y, Hupe, M, Crumrine, D, Lee, HJ, Gschwandtner, M, Thyssen, J, Trullas, C, Tschachler, E, Feingold, KR, Elias, PM. J Invest Dermatol. 133(2) 469-78 (2013).
Topical apigenin alleviates cutaneous inflammation in murine models. Man, M-Q, Hupe, M, Sun R, Man, G, Mauro T, Elias, PM Evidence-Based Compl & Alt Medicine. Online (2012).
Tight junction properties change during epidermis development. Celli, A, Zhai, Y, Jiang, YJ, Elias, PM. Exp Dermatol. 21(10): 820-821 (2012).
Urea uptake enhances barrier function and antimicrobial defense in humans by regulating epidermal gene expression. Grether-Beck, S, Felsner, I, Brenden, H, Elias, PM. J Invest Dermatol. 132, 1561-72 (2012).
Topical hesperidin improves epidermal permeability barrier function and epidermal differentiation in normal murine skin. Hou, M, Man, M, Man, W, Elias, PM. Exp Dermatol. 21, 337-40 (2012).
Cellular changes that accompany shedding of human corneocytes. Lin, TK, Crumrine, D, Ackerman, LD, Elias, PM. J Invest Dermatol. 132, 2430-9 (2012).
Cutaneous resonance running time is decreased in psoriatic lesions. Lv, C, Song, S, Luo, W, Elias, PM, Man, MQ. Skin Res Technol. 18, 232-7 (2012).
Cannabinoid receptors 1 and 2 oppositely regulate epidermal permeability barrier status and differentiation. Roelandt, T, Heughebaert, C, Bredif, S, Elias, PM. Exp Dermatol. 21, 688-93 (2012).
GPHR-Dependent Functions of the Golgi Apparatus Are Essential for the Formation of Lamellar Granules and the Skin Barrier Tarutani, M, Nakajima, K, Uchida, Y, Elias, PM. J Invest Dermatol. 132, 2019-25 (2012).
Xerosis is latitude dependent and affects the propensity to develop atopic disease. Thyssen, JP, Elias, PM. J Allergy Clin Immunol. 130, 820-1; author reply 821-2 (2012).
Ablation of the calcium-sensing receptor in keratinocytes impairs epidermal differentiation and barrier function. Tu, CL, Crumrine, DA, Man, MQ, Elias, PM. J Invest Dermatol. 132, 2350-9 (2012).
Pathogenesis-based therapy reverses cutaneous abnormalities in an inherited disorder of distal cholesterol metabolism. Paller, AS, van Steensel, MA, Rodriguez-Martin, M, Elias PM. J Invest Dermatol. 131, 2242-8 (2011).
Endoplasmic reticulum Ca(2+) depletion activates XBP1 and controls terminal differentiation in keratinocytes and epidermis. Celli, A, Mackenzie, DS, Crumrine, DS, Elias, PM. Br J Dermatol. 164, 16-25 (2011).
Skin ultrastructural findings in type 2 Gaucher disease: Diagnostic implications. Chan, A, Holleran, WM, Ferguson, T, Elias, PM. Mol Genet Metab. 104, 631-6 (2011).
Filaggrin genotype in ichthyosis vulgaris predicts abnormalities in epidermal structure and function. Gruber, R, Elias, PM, Crumrine, D, Elias, PM. Am J Pathol. 178, 2252-63 (2011).
Efficacy of combined peroxisome proliferator-activated receptor-alpha ligand and glucocorticoid therapy in a murine model of atopic dermatitis. Hatano, Y, Elias, PM, Crumrine, D. J Invest Dermatol. 131, 1845-52 (2011).
A topical Chinese herbal mixture improves epidermal permeability barrier function in normal murine skin. Man, M, Hupe, M, Mackenzie, D, Elias, PM. Exp Dermatol. 20, 285-8 (2011).
Topical herbal extract (Huangdang mixture) exhibits both preventive and therapeutic effects in murine acute irritant contact dermatitis. Man, W, Man, M, Hupe, M, Elias, PM. Int J Dermatol. 50, 1421-7 (2011).
Psychological stress regulates antimicrobial peptide expression by both glucocorticoid and beta-adrenergic mechanisms. Martin-Ezquerra, G, Man, MQ, Hupe, M, Elias, PM. Eur J Dermatol. 21 Suppl 2, 48-51 (2011).
Regulation of cathelicidin antimicrobial peptide expression by an endoplasmic reticulum (ER) stress signaling, vitamin D receptor-independent pathway. Park, K, Elias, PM, Oda, Y, Elias, PM. J Biol Chem. 286, 34121-30 (2011).
Aquaporin-3 in keratinocytes and skin: its role and interaction with phospholipase D2. Qin, H, Zheng, X, Zhong, X, Elias, PM. Arch Biochem Biophys. 508, 138-43 (2011).
Expression of epidermal CAMP changes in parallel with permeability barrier status. Rodriguez-Martin, M, Martin-Ezquerra, G, Man, MQ, Elias, PM. J Invest Dermatol. 131, 2263-70 (2011).
Actin dynamics regulate immediate PAR-2-dependent responses to acute epidermal permeability barrier abrogation. Roelandt, T, Heughebaert, C, Verween, G, Elias, PM. J Dermatol Sci. 61, 101-9 (2011).
Lipoxygenases mediate the effect of essential fatty acid in skin barrier formation: a proposed role in releasing omega-hydroxyceramide for construction of the corneocyte lipid envelope. Zheng, Y, Yin, H, Boeglin, WE, Elias, PM. J Biol Chem. 286, 24046-56 (2011).
Mitotic recombination in patients with ichthyosis causes reversion of dominant mutations in KRT10. Choate, KA, Lu, Y, Zhou, J, Elias, PM. Science. 330, 94-97 (2010).
Differential regulation of epidermal function by VDR coactivators. Bikle, DD, Teichert, A, Arnold, LA, Elias, PM. J Steroid Biochem Mol Biol. 121, 308-13 (2010).
Is the filaggrin-histidine-urocanic acid pathway essential for stratum corneum acidification? Fluhr, JW, Elias, PM, Man, MQ. J Invest Dermatol. 130, 2141-4 (2010).
Epidermal barrier dysfunction in non-atopic HIV: evidence for an “inside-to-outside” pathogenesis. Gunathilake, R, Schmuth, M, Scharschmidt, TC, Elias, PM. J Invest Dermatol. 130, 1185-8 (2010).
Acute acidification of stratum corneum membrane domains using polyhydroxyl acids improves lipid processing and inhibits degradation of corneodesmosomes. Hachem, JP, Roelandt, T, Schurer, N, Elias, PM. J Invest Dermatol. 130, 500-10 (2010).
Murine atopic dermatitis responds to peroxisome proliferator-activated receptors alpha and beta/delta (but not gamma) and liver X receptor activators. Hatano, Y, Man, MQ, Uchida, Y, Elias, PM. J Allergy Clin Immunol. 125, 160-9 e1-5 (2010)
IL-6 stimulates but is not essential for stratum corneum formation and permeability barrier development during gestation. Jiang, YJ, Lu, B, Crumrine, D, Elias, PM, Feingold, KR. Exp Dermatol. 19, e31-6 (2010).
Regulation of ABCG1 expression in human keratinocytes and murine epidermis. Jiang, YJ, Lu, B, Tarling, EJ, Elias, PM. J Lipid Res. 51, 3185-95 (2010).
PPARdelta activation promotes stratum corneum formation and epidermal permeability barrier development during late gestation. Jiang, YJ, Barish, G, Lu, B, Elias, PM. J Invest Dermatol. 130, 511-9 (2010).
Topical calcineurin inhibitors compromise stratum corneum integrity and epidermal and antimicrobial barrier function. Kim, M, Jung, M, Hong, S, Elias, PM. Exp Dermatol. 19, 501-510 (2010).
Epidermal permeability barrier recovery is delayed in vitiligo-involved sites. Liu, J, Man, WY, Lv, CZ, Elias, PM. Skin Pharmacol Physiol. 23, 193-200 (2010).
Expression and regulation of glycerol-3-phosphate acyltransferase isoforms in cultured human keratinocytes and rodent epidermis. Lu, B, Jiang, YJ, Kim, P, Elias, PM. J Lipid Res. (2010).
Neuroendocrine nicotinic receptor activation increases susceptibility to bacterial infections by suppressing antimicrobial peptide production. Radek, KA, Elias, PM, Taupenot, L. Cell Host Microbe. 7, 277-89 (2010).
Ichthyosis in Sjogren-Larsson syndrome reflects defective barrier function due to abnormal lamellar body structure and secretion. Rizzo, WB, S’Aulis, D, Jennings, MA, Williams, ML, Elias, PM. Arch Dermatol Res. 302, 443-51 (2010).
Hydrolytic pathway protects against ceramide-induced apoptosis in keratinocytes exposed to UVB. Uchida, Y, Houben, E, Park, K, Elias, PM. J Invest Dermatol. 130, 2472-80 (2010).
Neutral lipid storage leads to acylceramide deficiency, likely contributing to the pathogenesis of Dorfman-Chanarin syndrome. Uchida, Y, Cho, Y, Moradian, S, Elias, PM. J Invest Dermatol. 130, 2497-9 (2010).
Activators of PPARs and LXR decrease the adverse effects of exogenous glucocorticoids on the epidermis. Demerjian, M, Choi, EH, Man, MQ, Elias, PM. Exp Dermatol. 18, 643-649 (2009).
Maintenance of an acidic stratum corneum prevents emergence of murine atopic dermatitis. Hatano, Y, Man, MQ, Uchida, Y, Elias, PM. J Invest Dermatol. 129, 1824-35 (2009).
pH-regulated mechanisms account for pigment-type differences in epidermal barrier function. Gunathilake, R, Schurer, NY, Shoo, BA, Elias, PM. J Invest Dermatol. 129, 1719-29 (2009).
Ceramide stimulates ABCA12 expression via peroxisome proliferator-activated receptor {delta} in human keratinocytes. Jiang, YJ, Uchida, Y, Lu, B, Elias, PM. J Biol Chem. 284, 18942-52 (2009).
IL-1alpha accelerates stratum corneum formation and improves permeability barrier homeostasis during murine fetal development. Jiang, YJ, Lu, B, Crumrine, D, Elias, PM. J Dermatol Sci. 54, 88-98 (2009).
Variation of skin surface pH, sebum content and stratum corneum hydration with age and gender in a large Chinese population. Man, MQ, Xin, SJ, Song, SP, Elias, PM. Skin Pharmacol Physiol. 22, 190-9 (2009).
Vitamin D receptor and coactivators SRC2 and 3 regulate epidermis-specific sphingolipid production and permeability barrier formation. Oda, Y, Uchida, Y, Moradian, S, Elias, PM. J Invest Dermatol. 129, 1367-78 (2009).
Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens. Scharschmidt, TC, Man, MQ, Hatano, Y, Elias, PM. J Allergy Clin Immunol. 124, 496-506, 506 e1-6 (2009).
Abnormalities in stratum corneum function in patients recovered from leprosy. Song, SP, Lv, CZ, Feingold, KR, Elias, PM. Skin Pharmacol Physiol. 22, 131-6 (2009).
Topical peroxisome proliferator activated receptor activators accelerate postnatal stratum corneum acidification. Fluhr, JW, Man, MQ, Hachem, JP, Elias, PM. J Invest Dermatol. 129, 365-74 (2009).
The “Caveolae Brake Hypothesis” and the Epidermal Barrier. Roelandt, T, Giddelo, C, Heughebaert, C, Elias, PM. J Invest Dermatol. 129(4): 927-36 (2009).
Co-regulation and interdependence of the mammalian epidermal permeability and antimicrobial barriers. Aberg, KM, Man, MQ, Gallo, RL, Elias, PM. J Invest Dermatol. 128, 917-25 (2008).
Acute modulations in permeability barrier function regulate epidermal cornification: role of caspase-14 and the protease-activated receptor type 2. Demerjian, M, Hachem, JP, Tschachler, E, Elias, PM. Am J Pathol. 172, 86-97 (2008).
Epidermal vascular endothelial growth factor production is required for permeability barrier homeostasis, dermal angiogenesis, and the development of epidermal hyperplasia: implications for the pathogenesis of psoriasis. Elias, PM, Arbiser, J, Brown, BE. Am J Pathol. 173, 689-99 (2008).
Biopositive effects of low-dose UVB on epidermis: coordinate upregulation of antimicrobial peptides and permeability barrier reinforcement. Hong, SP, Kim, MJ, Jung, MY, Elias, PM. J Invest Dermatol. 128, 2880-7 (2008).
PPAR and LXR activators regulate ABCA12 expression in human keratinocytes. Jiang, YJ, Lu, B, Kim, P, Elias, PM. J Invest Dermatol. 128, 104-9 (2008).
Deficiency of PPARbeta/delta in the epidermis results in defective cutaneous permeability barrier homeostasis and increased inflammation. Man, MQ, Barish, GD, Schmuth, M, Elias, PM. J Invest Dermatol. 128, 370-7 (2008).
Characterization of a hapten-induced, murine model with multiple features of atopic dermatitis: structural, immunologic, and biochemical changes following single versus multiple oxazolone challenges. Man, MQ, Hatano, Y, Lee, SH, Elias, PM. J Invest Dermatol. 128, 79-86 (2008).
Chinese herbal medicine (Tuhuai extract) exhibits topical anti-proliferative and anti-inflammatory activity in murine disease models. Man, MQ, Shi, Y, Man, M, Elias, PM. Exp Dermatol. 17, 681-7 (2008).
The neuroendocrine peptide catestatin is a cutaneous antimicrobial and induced in the skin after injury. Radek, KA, Lopez-Garcia, B, Hupe, M, Elias, PM. J Invest Dermatol. 128, 1525-34 (2008).
Uchida, Y, Holleran, WM, Elias, PM. On the effects of topical synthetic pseudoceramides: Comparison of possible keratinocyte toxicities provoked by the pseudoceramides, PC104 and BIO391, and natural ceramides. J Dermatol Sci. 51, 37-43 (2008).
Psychological stress downregulates epidermal antimicrobial peptide expression and increases severity of cutaneous infections in mice. Aberg, KM, Radek, KA, Choi, EH, Elias, PM. J Clin Invest. 117, 3339-49 (2007).
Childhood Atopic Dermatitis Impact Scale: reliability, discriminative and concurrent validity, and responsiveness. Chamlin, SL, Lai, JS, Cella, D, Williams, ML. Arch Dermatol. 143, 768-72 (2007).
Stratum corneum acidification is impaired in moderately aged human and murine skin. Choi, EH, Man, MQ, Xu, P, Elias, PM. J Invest Dermatol. 127, 2847-56 (2007).
Potassium channel openers accelerate epidermal barrier recovery. Denda, M, Tsutsumi, M, Inoue, K, Elias, PM. Br J Dermatol. 157, 888-93 (2007).
Focal adhesion kinase controls pH-dependent epidermal barrier homeostasis by regulating actin-directed Na+/H+ exchanger 1 plasma membrane localization. Ilic, D, Mao-Qiang, M, Crumrine, D, Elias, PM. Am J Pathol. 170, 2055-67 (2007).
Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema. Sandilands, A, Terron-Kwiatkowski, A, Hull, PR, Elias, PM. Nat Genet. 39, 650-4 (2007).
Fatty acid 2-hydroxylase, encoded by FA2H, accounts for differentiation-associated increase in 2-OH ceramides during keratinocyte differentiation. Uchida, Y, Hama, H, Alderson, NL, Elias, PM. J Biol Chem. 282, 13211-9 (2007).
Loss of functional ELOVL4 depletes very long-chain fatty acids (> or =C28) and the unique omega-O-acylceramides in skin leading to neonatal death. Vasireddy, V, Uchida, Y, Salem, N, Jr., Elias, PM. Hum Mol Genet. 16, 471-82 (2007).
Study on skin surface pH in a normal Chinese population. Xin, S, Liu, Z, Feingold, KR, Elias, PM. J Clin Dermatol. 36, 289-290 (2007).
Study on the sebum content and stratum corneum hydration in the normal Chinese population. Xin, S, Liu, Z, Shi, Y, Elias, PM. J Clin Dermatol. 36, 131-133 (2007).
Hyaluronan-CD44 interaction stimulates keratinocyte differentiation, lamellar body formation/secretion, and permeability barrier homeostasis. Bourguignon, LY, Ramez, M, Gilad, E, Elias, PM. J Invest Dermatol. 126, 1356-65 (2006).
Glucocorticoid blockade reverses psychological stress-induced abnormalities in epidermal structure and function. Choi, EH, Demerjian, M, Crumrine, D, Elias, PM. Am J Physiol Regul Integr Comp Physiol. 291, R1657-62 (2006).
Barrier dysfunction and pathogenesis of neutral lipid storage disease with ichthyosis (Chanarin-Dorfman syndrome). Demerjian, M, Crumrine, DA, Milstone, LM, Williams, ML, Elias, PM. J Invest Dermatol. 126, 2032-8 (2006).
Topical treatment with thiazolidinediones, activators of peroxisome proliferator-activated receptor-gamma, normalizes epidermal homeostasis in a murine hyperproliferative disease model. Demerjian, M, Man, MQ, Choi, EH, Elias, PM. Exp Dermatol. 15, 154-60 (2006).
Serine protease signaling of epidermal permeability barrier homeostasis. Hachem, JP, Houben, E, Crumrine, D, Elias, PM. J Invest Dermatol. 126, 2074-86 (2006).
Serine protease activity and residual LEKTI expression determine phenotype in Netherton syndrome. Hachem, JP, Wagberg, F, Schmuth, M, Elias, PM. J Invest Dermatol. 126, 1609-21 (2006).
Skin abnormalities as an early predictor of neurologic outcome in Gaucher disease. Holleran, WM, Ziegler, SG, Goker-Alpan, O, Elias, PM. Clin Genet. 69, 355-7 (2006).
Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis. Houben, E, Holleran, WM, Yaginuma, T, Elias, PM. J Lipid Res. 47, 1063-70 (2006).
Basis for improved permeability barrier homeostasis induced by PPAR and LXR activators: liposensors stimulate lipid synthesis, lamellar body secretion, and post-secretory lipid processing. Man, MQ, Choi, EH, Schmuth, M, Elias, PM. J Invest Dermatol. 126, 386-92 (2006).
The objective severity assessment of atopic dermatitis (OSAAD) score: validity, reliability and sensitivity in adult patients with atopic dermatitis. Angelova-Fischer, I, Bauer, A, Hipler, UC, Williams, ML. Br J Dermatol. 153, 767-73 (2005).
Development of the Childhood Atopic Dermatitis Impact Scale: initial validation of a quality-of-life measure for young children with atopic dermatitis and their families. Chamlin, SL, Cella, D, Frieden, IJ, Williams, ML. J Invest Dermatol. 125, 1106-11 (2005).
The price of pruritus: sleep disturbance and cosleeping in atopic dermatitis. Chamlin, SL, Mattson, CL, Frieden, IJ, Williams, ML. Arch Pediatr Adolesc Med. 159, 745-50 (2005).
Mechanisms by which psychologic stress alters cutaneous permeability barrier homeostasis and stratum corneum integrity. Choi, EH, Brown, BE, Crumrine, D, Elias, PM. J Invest Dermatol. 124, 587-95 (2005).
Is endogenous glycerol a determinant of stratum corneum hydration in humans? Choi, EH, Man, MQ, Wang, F, Elias, PM. J Invest Dermatol. 125, 288-93 (2005).
Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity. Descargues, P, Deraison, C, Bonnart, C, Elias, PM. Nat Genet. 37, 56-65 (2005).
Topical liver X receptor activators accelerate postnatal acidification of stratum corneum and improve function in the neonate. Fluhr, JW, Crumrine, D, Mao-Qiang, M, Elias, PM. J Invest Dermatol. 125, 1206-14 (2005).
Extracellular pH Controls NHE1 expression in epidermis and keratinocytes: implications for barrier repair. Hachem, JP, Behne, M, Aronchik, I, Elias, PM. J Invest Dermatol. 125, 790-7 (2005).
Sustained serine proteases activity by prolonged increase in pH leads to degradation of lipid processing enzymes and profound alterations of barrier function and stratum corneum integrity. Hachem, JP, Man, MQ, Crumrine, D, Elias, PM. J Invest Dermatol. 125, 510-20 (2005).
LXR and PPAR activators stimulate cholesterol sulfotransferase type 2 isoform 1b in human keratinocytes. Jiang, YJ, Kim, P, Elias, PM, Feingold, KR. J Lipid Res. 46, 2657-66 (2005).
Expression and regulation of 1-acyl-sn-glycerol- 3-phosphate acyltransferases in the epidermis. Lu, B, Jiang, YJ, Man, MQ, Elias, PM. J Lipid Res. 46, 2448-57 (2005).
Stearoyl-CoA desaturase-2 gene expression is required for lipid synthesis during early skin and liver development. Miyazaki, M, Dobrzyn, A, Elias, PM, Ntambi, JM. Proc Natl Acad Sci U S A. 102, 12501-6 (2005).
Structural changes in epidermal scale and appendages as indicators of defective TGM1 activity. Rice, RH, Crumrine, D, Uchida, Y, Gruber, R, Elias, PM. Arch Dermatol Res. 297, 127-33 (2005).
Differential expression of fatty acid transport proteins in epidermis and skin appendages. Schmuth, M, Ortegon, AM, Mao-Qiang, M, Elias, PM. J Invest Dermatol. 125, 1174-81 (2005).
A homolog of Drosophila grainy head is essential for epidermal integrity in mice. Ting, SB, Caddy, J, Hislop, N, Elias, PM. Science. 308, 411-3 (2005).
The epidermis of grhl3-null mice displays altered lipid processing and cellular hyperproliferation. Ting, SB, Caddy, J, Wilanowski, T, Elias, PM. Organogenesis. 2, 33-5 (2005).
Imiquimod-induced interleukin-1 alpha stimulation improves barrier homeostasis in aged murine epidermis. Barland, CO, Zettersten, E, Brown, BS, Elias, PM. J Invest Dermatol. 122, 330-6 (2004).
25 Hydroxyvitamin D 1 alpha-hydroxylase is required for optimal epidermal differentiation and permeability barrier homeostasis. Bikle, DD, Chang, S, Crumrine, D, Elias, PM. J Invest Dermatol. 122, 984-92 (2004).
Mice lacking 25OHD 1alpha-hydroxylase demonstrate decreased epidermal differentiation and barrier function. Bikle, DD, Chang, S, Crumrine, D, Elias, PM. J Steroid Biochem Mol Biol. 89-90, 347-53 (2004).
Effects of atopic dermatitis on young American children and their families. Chamlin, SL, Frieden, IJ, Williams, ML, Chren, MM. Pediatrics. 114, 607-11 (2004).
Basis for abnormal desquamation and permeability barrier dysfunction in RXLI. Elias, PM, Crumrine, D, Rassner, U, Williams, ML. J Invest Dermatol. 122, 314-9 (2004).
Functional consequences of a neutral pH in neonatal rat stratum corneum. Fluhr, JW, Mao-Qiang, M, Brown, BE, Hachem JP, Moskowitz DG, Demerjian M, Haftek M, Serre G, Crumrine D, Mauro TM, Elias PM, Feingold KR. J Invest Dermatol. 123, 140-51 (2004).
Stratum corneum acidification in neonatal skin: secretory phospholipase A2 and the sodium/hydrogen antiporter-1 acidify neonatal rat stratum corneum. Fluhr, JW, Behne, MJ, Brown, BE, Elias, PM. J Invest Dermatol. 122, 320-9 (2004).
Nutritional status and gastrointestinal structure and function in children with ichthyosis and growth failure. Fowler, AJ, Moskowitz, DG, Wong, A, Williams, ML. J Pediatr Gastroenterol Nutr. 38, 164-9 (2004).
Epidermal-Specific Defect of GPI Anchor in Pig-a Null Mice Results in Harlequin Ichthyosis-Like Features. Hara-Chikuma, M, Takeda, J, Tarutani, M, Elias, PM. J Invest Dermatol. 123, 464-9 (2004).
Peroxisome-proliferator-activated receptor (PPAR)-gamma activation stimulates keratinocyte differentiation. Man, MQ, Fowler, AJ, Schmuth, M, Elias, PM. J Invest Dermatol. 123, 305-12 (2004).
Pathophysiologic basis for growth failure in children with ichthyosis: an evaluation of cutaneous ultrastructure, epidermal permeability barrier function, and energy expenditure. Moskowitz, DG, Fowler, AJ, Heyman, MB, Elias, PM, Williams, ML. J Pediatr. 145, 82-92 (2004).
Barrier function in transgenic mice overexpressing k16, involucrin, and filaggrin in the suprabasal epidermis. Presland, RB, Coulombe, PA, Eckert, RL, Elias, PM. Invest Dermatol. 123, 603-6 (2004).
The Effect of LXR Activators on AP-1 Proteins in Keratinocytes. Schmuth, M, Elias, PM, Hanley, K. J Invest Dermatol. 123, 41-8 (2004).
Structural and functional consequences of loricrin mutations in human loricrin keratoderma (Vohwinkel syndrome with ichthyosis). Schmuth, M, Fluhr, JW, Crumrine, DC, Elias, PM. J Invest Dermatol. 122, 909-22 (2004).
Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes. Schmuth, M, Haqq, CM, Cairns, WJ, Elias, PM. J Invest Dermatol. 122, 971-83 (2004).
Lipopenia and skin barrier abnormalities in DGAT2-deficient mice. Stone, SJ, Myers, HM, Watkins, SM, Elias, PM. J Biol Chem. 279, 11767-76 (2004).
Role for ELOVL3 and Fatty Acid Chain Length in Development of Hair and Skin Function. Westerberg, R, Tvrdik, P, Unden, AB, Elias, PM. J Biol Chem. 279, 5621-9 (2004).
Neonatal development of the stratum corneum pH gradient: localization and mechanisms leading to emergence of optimal barrier function. Behne, MJ, Barry, NP, Hanson, KM, Elias, PM. J Invest Dermatol. 120, 998-1006 (2003).
Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production. Fowler, AJ, Sheu, MY, Schmuth, M, Elias, PM. J Invest Dermatol. 120, 246-55 (2003).
Glycerol regulates stratum corneum hydration in sebaceous gland deficient (asebia) mice. Fluhr, JW, Mao-Qiang, M, Brown, BE, Elias, PM. J Invest Dermatol. 120, 728-37 (2003).
pH directly regulates epidermal permeability barrier homeostasis, and stratum corneum integrity/cohesion. Hachem, JP, Crumrine, D, Fluhr, J, Elias, PM. J Invest Dermatol. 121, 345-53 (2003).
Short-term glucocorticoid treatment compromises both permeability barrier homeostasis and stratum corneum integrity: inhibition of epidermal lipid synthesis accounts for functional abnormalities. Kao, JS, Fluhr, JW, Man, MQ, Elias, PM. Invest Dermatol. 120, 456-64 (2003).
Cross-linked envelopes in nail plate in lamellar ichthyosis. Rice, RH, Crumrine, D, Hohl, D, Munro, CS, Elias, PM. Br J Dermatol. 149, 1050-1054 (2003).
The objective severity assessment of atopic dermatitis score: an objective measure using permeability barrier function and stratum corneum hydration with computer-assisted estimates for extent of disease. Sugarman, JL, Fluhr, JW, Fowler, AJ, Williams, ML. Arch Dermatol. 139, 1417-1422 (2003).
De novo ceramide synthesis participates in the ultraviolet B irradiation-induced apoptosis in undifferentiated cultured human keratinocytes. Uchida, Y, Nardo, AD, Collins, V, Elias, PM, Holleran, WM. J Invest Dermatol. 120, 662-9 (2003).
NHE1 regulates the stratum corneum permeability barrier homeostasis. Microenvironment acidification assessed with fluorescence lifetime imaging.Behne, MJ, Meyer, JW, Hanson, KM, Elias, PM. J Biol Chem. 277, 47399-406 (2002).
Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis: changes in barrier function provide a sensitive indicator of disease activity. Chamlin, SL, Kao, J, Frieden, IJ, Williams, ML, Elias, PM. J Am Acad Dermatol. 47, 198-208 (2002).
Impact of topical oils on the skin barrier: possible implications for neonatal health in developing countries. Darmstadt, GL, Mao-Qiang, M, Chi, E, Elias, PM. Acta Paediatr. 91, 546-54 (2002).
Origin of the epidermal calcium gradient: regulation by barrier status and role of active vs passive mechanisms. Elias, PM, Ahn, S, Brown, B, Crumrine, D, Feingold, KR. J Invest Dermatol. 119, 1269-74 (2002).
Modulations in epidermal calcium regulate the expression of differentiation-specific markers. Elias, PM, Ahn, S, Denda, M. J Invest Dermatol. 119, 1128-36 (2002).
Basis for the permeability barrier abnormality in lamellar ichthyosis. Elias, PM, Schmuth, M, Uchida, Y. Exp Dermatol. 11, 248-56 (2002).
Fatal septicemia in an infant with keratitis, ichthyosis, and deafness (KID) syndrome. Gilliam, A, Williams, ML. Pediatr Dermatol. 19, 232-6 (2002).
Oxysterol stimulation of epidermal differentiation is mediated by liver X receptor-beta in murine epidermis. Komuves, LG, Schmuth, M, Fowler, AJ, Elias, PM. J Invest Dermatol. 118, 25-34 (2002).
The ENaC channel is required for normal epidermal differentiation. Mauro, T, Guitard, M, Behne, M, Elias, PM. J Invest Dermatol. 118, 589-94 (2002).
Abrupt decreases in environmental humidity induce abnormalities in permeability barrier homeostasis. Sato, J, Denda, M, Chang, S, Elias, PM, Feingold, KR. J Invest Dermatol. 119, 900-4 (2002).
Role of peroxisome proliferator-activated receptor alpha in epidermal development in utero. Schmuth, M, Schoonjans, K, Yu, QC, Elias, PM. J Invest Dermatol. 119, 1298-303 (2002).
Topical corticosteroid therapy for acute radiation dermatitis: a prospective, randomized, double-blind study. Schmuth, M, Wimmer, MA, Hofer, S, Elias, PM. Br J Dermatol. 146, 983-91 (2002).
Topical peroxisome proliferator activated receptor-alpha activators reduce inflammation in irritant and allergic contact dermatitis models. Sheu, MY, Fowler, AJ, Kao, J, Elias, PM. J Invest Dermatol. 118, 94-101 (2002).
Scavenger receptor class B type I is expressed in cultured keratinocytes and epidermis. Regulation in response to changes in cholesterol homeostasis and barrier requirements. Tsuruoka, H, Khovidhunkit, W, Brown, BE, Elias, PM. J Biol Chem. 277, 2916-22 (2002).
Glucosylceramide synthesis and synthase expression protect against ceramide-induced stress. Uchida, Y, Murata, S, Schmuth, M, Elias, PM. J Lipid Res. 43, 1293-302 (2002).
Alterations in cytokine regulation in aged epidermis: implications for permeability barrier homeostasis and inflammation. I. IL-1 gene family. Ye, J, Garg, A, Calhoun, C, Elias, PM. Exp Dermatol. 11, 209-16 (2002).
Significant absorption of topical tacrolimus in 3 patients with Netherton syndrome. Allen, A, Siegfried, E, Silverman, R, Elias, PM. Arch Dermatol. 137, 747-50 (2001).
The antiporter NHE1 influences the function of the SC pH gradient. Behne, M, Elias, PM, Mauro, T. J Skin Barrier Res. 3, 3-10 (2001).
Ceramide-dominant, barrier-repair lipids improve childhood atopic dermatitis. Chamlin, SL, Frieden, IJ, Fowler, A, Williams, ML, Elias, PM. Arch Dermatol. 137, 1110-2 (2001).
Desmoglein isoform distribution affects stratum corneum structure and function. Elias, PM, Matsuyoshi, N, Wu, H, et al. J Cell Biol. 153, 243-9 (2001).
Generation of free fatty acids from phospholipids regulates stratum corneum acidification and integrity. Fluhr, JW, Kao, J, Jain, M, Elias, PM. J Invest Dermatol. 117, 44-51 (2001).
Psychological stress perturbs epidermal permeability barrier homeostasis: implications for the pathogenesis of stress-associated skin disorders. Garg, A, Chren, MM, Sands, LP, Elias, PM. Arch Dermatol. 137, 53-9 (2001).
Cholesterol sulfate stimulates involucrin transcription in keratinocytes by increasing Fra-1, Fra-2, and Jun D. Hanley, K, Wood, L, Ng, DC, Elias, PM. Lipid Res. 42, 390-8 (2001).
Testosterone perturbs epidermal permeability barrier homeostasis. Kao, JS, Garg, A, Mao-Qiang, M, Elias, PM. Invest Dermatol. 116, 443-51 (2001).
Pathogenesis of the permeability barrier abnormality in epidermolytic hyperkeratosis. Schmuth, M, Yosipovitch, G, Williams, ML,Hintner, H., Rappersberger, K., Crumrine, D., Feingold, K.R., Elias, P.M. J Invest Dermatol. 117, 837-47 (2001).
Vitamin C stimulates sphingolipid production and markers of barrier formation in submerged human keratinocyte cultures. Uchida, Y, Behne, M, Quiec, D, Elias, PM, Holleran, WM. J Invest Dermatol. 117, 1307-13 (2001).
Intralesional steroids reduce inflammation from extravasated chemotherapeutic agents. Whang, SW, Lee, SH, Elias, PM. Br J Dermatol. 145, 680-2 (2001).
Omega-hydroxyceramides are required for corneocyte lipid envelope (CLE) formation and normal epidermal permeability barrier function. Behne, M, Uchida, Y, Seki, T, Elias, PM. J Invest Dermatol. 114, 185-92 (2000).
Stress alters cutaneous permeability barrier homeostasis. Denda, M, Tsuchiya, T, Elias, PM, Feingold, KR. Am J Physiol Regul Integr Comp Physiol. 278, R367-72 (2000).
Origin of the corneocyte lipid envelope (CLE): observations in harlequin ichthyosis and cultured human keratinocytes. Elias, PM, Fartasch, M, Crumrine, D. J Invest Dermatol. 115, 765-9 (2000).
Farnesol stimulates differentiation in epidermal keratinocytes via PPARalpha. Hanley, K, Komuves, LG, Ng, DC, Elias, PM. J Biol Chem. 275, 11484-91 (2000).
Oxysterols induce differentiation in human keratinocytes and increase Ap-1-dependent involucrin transcription. Hanley, K, Ng, DC, He, SS, Elias, PM. J Invest Dermatol. 114, 545-53 (2000).
Structural and functional effects of oleic acid and iontophoresis on hairless mouse stratum corneum. Jiang, SJ, Hwang, SM, Choi, EH, Elias, PM. J Invest Dermatol. 114, 64-70 (2000).
Stimulation of PPARalpha promotes epidermal keratinocyte differentiation in vivo. Komuves, LG, Hanley, K, Lefebvre, AM, Elias, PM. J Invest Dermatol. 115, 353-60. (2000).
Keratinocyte differentiation in hyperproliferative epidermis: topical application of PPARalpha activators restores tissue homeostasis. Komuves, LG, Hanley, K, Man, MQ, Elias, PM. J Invest Dermatol. 115, 361-7 (2000).
Permeability barrier disorder in Niemann-Pick disease: sphingomyelin-ceramide processing required for normal barrier homeostasis. Schmuth, M, Man, MQ, Weber, F, Elias, PM. J Invest Dermatol. 115, 459-66 (2000).
Epidermal sphingomyelins are precursors for selected stratum corneum ceramides. Uchida, Y, Hara, M, Nishio, H, Elias, PM. J Lipid Res. 41, 2071-82 (2000).
REVIEW ARTICLES/BOOK CHAPTERS
The how, why and clinical importance of stratum corneum acidification. Elias, PM. Exp Dermatol. 26(11): 999-1003, 2017.
It remains unknown whether filaggrin gene mutations evolved to increase cutaneous synthesis of vitamin D. Thyssen, JP. and Elias, PM. Genome Biol Evol. 9(4): 900-901, 2017.
Defining gaps in dermatitis care. Nedorost, S., Atwater, A., Ardern-Jones, M., Elias, PM., Mukherjee, P., Honari, G., Ertel, M., Hammond, M., Machler, B., Scheman, A., Mulligan, K., Montanez-Wiskovich, M., Jacob, S., Brod, B. Dermatitis 28(6): 372-375, 2017.
Herbal medicines prevent the development of atopic dermatitis by multiple mechanisms. Man, MQ., Hu, LZ., Elias, PM. Chin J Integr Med. Online Publication, 2016.
Atopic Dermatitis Update – AD is more than one disease. Elias, PM. Exchange, National Eczema Society Members’ Magazine, 160: 28-30, 2016.
Basis for the gain and subsequent dilution of epidermal pigmentation during human evolution: the barrier and metabolic conservation hypotheses revisited. Elias, PM. and Williams, ML. Amer J Phys Anthropol. 161(2): 189-207, 2016.
Sensitive skin and its management. Man, MQ., Jeong, SK., Park, BD., Elias, PM. Chin J Dermatol. 49(12): 74-77, 2016.
The vitamin D hypothesis: dead or alive? Elias, PM., Williams, ML., Bikle, DD. Am J Phys Anthropol Online Publication, 2016.
Invited commentary: stratum corneum acidification: how and why? Elias, PM. Exper Dermatol. 24(3): 179-180, 2015.
Epidermis as a dynamic interface. Elias, PM., Feingold, K.R. Old Herborn Lecture Monograph 28, pg 1-17, 2015.
Comment on from bench to bedside: where’s the beef? Elias, PM. Science Online Publication 2015.
Physiologic Lipids for Barrier Repair. Elias, PM. In: Cosmeceuticals. 3rd Edition, Editors: Z. Draelos, J. Dover, M. Alam. Elsevier, pgs 49-54, 2015.
An integrated view of the epidermal environmental interface. Elias, PM., Wakefield, JS. Dermatol Sinica. 33(2): 49-57, 2015.
Therapeutic benefits of enhancing permeability barrier for atopic eczema. Man, G., Elias, PM., Man, M-Q. Dermatol Sinica. 33(2): 84-89, 2015.
Herbal medicines that benefit epidermal permeability barrier function. Hu, LZ., Man, HB., Elias, PM., Man, M-Q. Dermatol Sinica. 33(2): 90-95, 2015.
An optimized inexpensive emollient mixture improves barrier repair in murine skin. Man, G., Cheung, C., Crumrine, D., Hupe, M., Hill, Z., Man, M-Q., Elias, PM. Dermatol Sinica. 33(2): 96-102, 2015.
Atopic dermatitis update: AD is more than one disease. Elias, PM. Natl Eczema Assn “The Advocate,” 2015.
Potential role of reduced environmental UV exposure as a ‘driver’ of the current epidemic of atopic dermatitis. Thyssen, JP., Zirwas, MJ., Elias, PM. J Allergy Clin Immunol. 136(5): 1163-9, 2015.
Evolution of Skin Color. In:Basics in Human Evolution. Vol 1. Elias, PM and Williams, ML. Edtr: Muehlenbein, M., Elsevier, London, pp 273-283 (2015).
Care of the Newborn with Ichthyosis. In: Neonatology: Clinical Practice and Procedures. Dyer, JA and Williams, ML. Edtrs: Stevenson, D.K., Cohen, R.S., Sunshine, P., McGraw Hill Education, New York, pp 1357-1361 (2015).
Invited commentary: stratum corneum acidification: how and why? Elias, PM. Exper Dermatol. 24, 179-180 (2015).
Epidermis as a dynamic interface. Elias, PM, Feingold, KR. Old Herborn Lecture Monograph 28, 1-17 (2015).
Formation and functions of the corneocyte lipid envelope. Elias, PM., Gruber, R., Crumrine, D., Menon, G.,Williams, ML., Holleran, WM., Uchida, Y. BBA – Molecular and Cell Biology of Lipids. 1841(3) 314-318, 2014.
Evidence that loss-of-function filaggrin mutations evolved in northern Europeans to favor intracutaneous vitamin D3 production. Thyssen, JP., Bikle, DD., Elias, PM. Evol. Biol. 41(3): 388-396, 2014.
Skin barrier repair in atopic dermatitis therapy. Abramovits, W., Elias, PM. In: Atopic dermatitis and eczematous disorders. Edtr: Rudikoff, D, Cohen, S.R., Scheinfeld. CRC Press, Taylor & Francis Grp, Publisher, pgs. 159-164, 2014.
Mechanisms of abnormal lamellar body secretion and the dysfunctional skin barrier in atopic dermatitis. Elias, P.M., Wakefield, J.S. J Allergy & Clin Immun. 134(4): 781-791, 2014.
Role of lipids in the formation and maintenance of the cutaneous permeability barrier. Feingold, KR, Elias, PM. BBA – Molecular and Cell Biology of Lipids. 1841, 280-294 (2014).
Role of cholesterol sulfate in epidermal structure and function: lessons from x-linked ichthyosis. Elias, PM, Williams, ML, Cho, E-H, Feingold, KR. BBA – Molecular and Cell Biology of Lipids. 1841, 353-361 (2014).
Formation and functions of the corneocyte lipid envelope. Elias, PM., Gruber, R., Crumrine, D., Menon, G.,Williams, ML., Holleran, WM., Uchida, Y. BBA – Molecular and Cell Biology of Lipids. 1841(3) 314-318, 2014.
Lipid abnormalities and lipid-based repair strategies in atopic dermatitis.Elias, PM, Wakefield, JS. BBA – Molecular and Cell Biology of Lipids. 1841, 323-330 (2014).
Mechanisms of abnormal lamellar body secretion and the dysfunctional skin barrier in atopic dermatitis. Elias, PM, Wakefield, JS. J Allergy & Clin Immun. 134, 781-791 (2014).
Ichthyosis vulgaris – the filaggrin mutation disease. Thyssen, JP, Godoy-Gijon, E, Elias, PM. Brit J Dermatol. 168, 1155-1166 (2013).
Comment on ‘Does a history of eczema predict a future basal cell carcinoma?’ Elias, PM, Williams, ML. J Invest Dermatol. 133, 1676-1677 (2013).
Re-appraisal of current theories for the development and loss of epidermal pigmentation in hominins and modern humans. Elias, PM, Williams, ML. J Human Evol. 64, 687-692 (2013).
Treating atopic dermatitis at the source: corrective barrier repair therapy based upon new pathogenic insights. Elias, PM, Sun, R, Eder, AR, Wakefield, JS, Man, MQ. Exp Rev of Dermatol. 8(1): 27-46 (2013).
Pathogenesis-based therapies in ichthyoses. Lai-Cheong, JE, Elias, PM, Paller, AS. Dermatol Therapy. 26(1): 46-54 (2013).
New Perspectives in the Treatment of Leg Ulcers. Godoy-Gijon, E, Qiang Man, M, Thyssen, JP, Elias, PM. Acta Dermosifiliogr. 104(3):254-5 (2013).
Structure and function of the stratum corneum extracellular matrix. Elias, PM. J Invest Dermatol. 132, 2131-3 (2012).
Role Of Stratum Corneum In Permeability Barrier Function And Antimicrobial Defense Elias PM and Lin SK. In: Innate Immunity of Skin and Oral Mucosa Dayan, N and Wertz, PW (Ed.). John Wiley, pp. 59-72 (2011).
Ichthyoses and related mendelian disorders of cornification (MEDOC). Hohl, D, Williams, ML. In: Harper’s Textbook of Pediatric Dermatology. Irvine, A, Hoeger, P, and Yan, A (Ed.) Wiley Blackwell, Chapter 121, pp 121.1-12.170 (2011).
Therapeutic implications of a barrier-based pathogenesis of atopic dermatitis. Elias, PM, Wakefield, JS. Clin Rev Allergy Immunol. 41, 282-95 (2011).
Abnormal skin barrier in the pathogenesis of atopic dermatitis. Elias, PM Natl Eczema Assn News, pg 2, (2010).
Defensive functions of the stratum corneum: integrative aspects. Elias, PM. In: Toxicology of the Skin. Monteiro-Riviere, NA (Ed.), Informa Healthcare, New York, 19-28 (2010).
Skin barrier function. Elias, PM, Wakefield, JS.In: Nutrition for Healthy Skin. Krutmann, J and Humbert, JE (Ed.), Springer-Verlag, Berlin, 35-48 (2010).
Ichthyoses – Clinical, Biochemical, Pathogenic, and Diagnostic Assessment. Elias, PM, Williams, ML, Crumrine, D, Schmuth, M Current Problems in Dermatology. Vol. 39. Basel: S. Kargar AG. 144 p (2010).
Therapeutic implications of a barrier-based pathogenesis of atopic dermatitis. Elias, PM. Ann Dermatol. 22, 245-54 (2010).
Barrier requirements as the evolutionary “driver” of epidermal pigmentation in humans. Elias, PM, Menon, G, Wetzel, BK, Williams, JJ. Am J Hum Biol. 22, 526-37 (2010).
Revised nomenclature and classification of inherited ichthyoses: results of the First Ichthyosis Consensus Conference in Soreze 2009. Oji, V, Tadini, G, Akiyama, M, Oji, V., Tadini, G., Akiyama, M., Bardon, C.B., Bodemer, C., Bourrat, E., Coudiere, P., DiGiovanna, J.J., Elias, P.M., Fischer, J., Fleckman, P., Gina, M., Harper, J., Hashimoto, T., Hausser, I., Hennies, H.C., Hohl, D., Hovnanian, A., Ishida-Yamamoto, A., Jacyk, W.K., Leachman, S., Leigh, I., Mazereeuw-Hautier, J., Milstone, L., Morice-Picard, F., Paller, A.S., Richard, G., Schmuth, M., Shimizu, H., Sprecher, E., VanSteensel, M., Taieb, A., Toro, J., Vabres, P., Vahlquist, A., Williams, M., Traupe, H. et al.J Am Acad Dermatol. 63, 607-41 (2010).
An appropriate response to the black-box warning: corrective, barrier repair therapy in atopic dermatitis. Elias, PM. Clin Medicine: Dermatol. 2, 1-3 (2009).
Evidence that stress to the epidermal barrier influenced the development of pigmentation in humans. Elias, PM, Menon, G, Wetzel, BK, Williams, JJ. Pigment Cell Melanoma Res. 22, 420-34 (2009).
Abnormal skin barrier in the etio-pathogenesis of atopic dermatitis. Elias, PM, Schmuth, M. Curr Allergy Asthma Rep. 9, 265-272 (2009).
Physiologic lipids for barrier repair in dermatology. Elias, PM. In: Cosmeceuticals: Procedures in Cosmetic Dermatology. Draelos, ZD (Ed.), Saunders Elsevier, New York, 61-68 (2009).
Relationship of Netherton syndrome to atopic dermatitis. Elias, PM, Williams, ML. Ichthyosis Focus. 28, 1, 7 (2009).
Barrier-repair therapy for atopic dermatitis: corrective lipid biochemical therapy. Elias, PM. Exp Rev of Dermatol. 3, 441-452 (2008).
Skin barrier function. Elias, PM.Curr Allergy Asthma Rep. 8, 299-305 (2008).
Basis for the barrier abnormality in atopic dermatitis: outside-inside-outside pathogenic mechanisms. Elias, PM, Hatano, Y, Williams, ML. J Allergy Clin Immunol. 121, 1337-43 (2008).
“Outside-to-inside” (and now back to “outside”) pathogenic mechanisms in atopic dermatitis. Elias, PM, Steinhoff, M. J Invest Dermatol. 128, 1067-70 (2008).
Pathogenesis of permeability barrier abnormalities in the ichthyoses: inherited disorders of lipid metabolism. Elias, PM, Williams, ML, Holleran, WM, Jiang, YJ, Schmuth, M.J Lipid Res. 49, 697-714 (2008).
Thematic Review Series: Skin Lipids. Peroxisome proliferator-activated receptors and liver X receptors in epidermal biology. Schmuth, M, Jiang, YJ, Dubrac, S, Elias, PM, Feingold, KR.J Lipid Res. 49, 499-509 (2008).
Barrier repair as primary therapy in dermatology: rationale and early results. Elias, PM. Aesth Dermatol News. 3, 24-27 (2008).
Barrier repair trumps immunology in the pathogenesis and therapy of atopic dermatitis. Elias, PM.Drug Discov Today. 5, e33-e38 (2008).
Skin as an endocrine organ: implications for its function. Slominski, A, Wortsman, J, Paus, R,Tobin, D.J., Feingold, K.R., Elias, P.M Drug Discov Today. 5, e137-e144 (2008).
The skin barrier as an innate immune element. Elias, PM. Sem Immunopath. 29, 3-14 (2007).
The regulation of permeability barrier homeostasis. Feingold, KR, Schmuth, M, Elias, PM. J Invest Dermatol. 127, 1574-6 (2007).
Ichthyosis update: towards a function- driven model of pathogenesis of the disorders of cornification and the role of corneocyte proteins in these disorders. Schmuth, M, Gruber, R, Elias PM, Williams, M.Adv Dermatol. 23, 231-256 (2007).
Skin barrier structure and function and their relationship to pruritus in end-stage renal disease. Yosipovitch, G, Duque, MI, Patel, TS, Ishiuji, Y., Guzman-Sanchez, D.A., Dawn, A.G., Freedman, B.I., Chan, Y.H., Crumrine, D., Elias, P.M. Nephrol Dial Transplant. (2007).
Book Review of “Skin: A Natural History” by Nina Jablonski. Elias, PM, Mauro, TM.In: The Quarterly Review of Biology. Carlson, AD (Ed.), University of Chicago Press, Chicago, 180-181 (2007).
Understanding and exploiting the important role of barrier function. Elias, PM, Pigeon, T. Practical Dermatology. 70-75 (2007).
Permeability and antioxidant barriers in aged epidermis. Thiele, J, Barland, CO, Elias, PM, Ghadially, R.In: Skin Aging. Gilchrest, BA and Krutmann, J (Ed.), Springer, Berlin Heidelberg, 65-79 (2006).?
Transepidermal water loss reflects permeability barrier status: validation in human and rodent in vivo and ex vivo models. Fluhr, J.W., Feingold, K.R., Elias, P.M Exp Dermatol. 15, 483-92 (2006).
The aged epidermal barrier: basis for functional abnormalities. Barland, CO, Elias, P.M., Ghadially, R.In: Skin Barrier. Elias, PM, Feingold, K.R. (Ed.), Marcel Dekker, New York, 535-552 (2005).
Defensive functions of the stratum corneum: integrative aspects. Elias, PM. In: Skin Barrier. Elias, PM and Feingold, KR (Ed.), Marcel Dekker, New York, 5-14 (2005).
The epidermal permeability barrier: from Saran Wrap to biosensor. Elias, PM. In: Skin Barrier. Elias, PM and Feingold, KR (Ed.), Marcel Dekker, New York, 25-31 (2005).
Epilogue: fixing the barrier – theory and rational deployment.Elias, PM. In: Skin Barrier. Elias, PM and Feingold, KR (Ed.), Marcel Dekker, New York, 591-600 (2005).
Formation and function of the stratum corneum acid mantle.Elias, PM. In: Stratum Corneum: the Vital Structure. Marks, R, Matts, P, and Leveque, J (Ed.), The Stratum Corneum Group, Cardiff, 1-4 (2005).
Physiological lipids for barrier repair in dermatology. Elias, PM. In: Procedures in Cosmetic Dermatology: Cosmeceuticals. Dover, JS, Alam, MS, and Draelos, ZD (Ed.), Elsevier, London, 63-70 (2005).
Pathogenesis of desquamation and permeability barrier abnormalities in RXLI. Elias, PM, Crumrine, D, Rassner, U, Menon, G.K., Feingold, K.R., Williams, M.L. In: Skin Barrier. Elias, PM and Feingold, KR (Ed.), Marcel Dekker, New York, 511-518 (2005).
Stratum corneum barrier function: definitions and broad concepts. Elias, PM, Feingold, KR In: Skin Barrier. Elias, PM and Feingold, KR (Ed.), Marcel Dekker, New York, 1-4 (2005).
Permeability barrier homeostasis. Elias, PM, Feingold, KR.In: Skin Barrier. Elias, PM and Feingold, KR (Ed.), Marcel Dekker, New York, 337-362 (2005).
The epidermal lamellar body as a multifunctional secrectory organelle. Elias, PM, Feingold, KR, Fartasch, M.In: Skin Barrier. Elias, PM and Feingold, KR (Ed.), Marcel Dekker, New York, 261-272 (2005).
The stratum corneum of the epidermis in atopic dermatitis. Jensen, JM, Proksch, E, Elias, PM.In: Skin Barrier. Elias, PM and Feingold, KR (Ed.), Marcel Dekker, New York, 569-590 (2005).
The role of the primary cytokines, TNF, IL-1, and IL-6, in permeability barrier homeostasis. Lu, B, Elias, PM, Feingold, KRIn: Skin Barrier. Elias, PM and Feingold, KR (Ed.), Marcel Dekker, New York, 305-318 (2005).
Pathogenesis of the barrier abnormalities in disorders of cornification.Schmuth, M, Elias, PM, Williams, ML. In: Skin Barrier. Elias, PM and Feingold, KR (Ed.), Marcel Dekker, New York, 469-510 (2005).
Stratum corneum defensive functions: an integrated view. Elias, PM.J Invest Dermatol. 125, 183-200 (2005).
Interactions among stratum corneum defensive functions. Choi, EH. Exp Dermatol. 14, 719-26 (2005).
The epidermal lamellar body: a multifunctional, secretory organelle. Elias, P, Feingold, K.J Skin Barrier Res. 7, 11-22 (2005).
The role of PPARs and LXRs in the regulation of epidermal structure and function.Feingold, KR, Elias, PM, Schmuth, M, Man, M-Q. J Skin Barrier Res. 7, 53-64 (2005).
Pathogenesis of the Ichthyoses: Update and Therapeutic Implications. Williams, ML, Schmuth, M, Crumrine, D, et al. J Skin Barrier Res. 7, 122-133 (2005).
The epidermal permeability barrier: from the early days at Harvard to emerging concepts. Elias, PM.J Invest Dermatol. 122, XXXVI-IX (2004).
Skin as an organ of protection. Elias, PM, Feingold, KR, Fluhr, JW. Fitzpatrick’s Dermatology in General Medicine, 6th Edition. 107-118 (2003).
Skin barrier and percutaneous drug delivery.Elias, P, Tsai, J, Menon, G, Holleran, W, Feingold, K. In: Dermatology. Bolognia, J, Jorizzo, J, and Rapini, R (Ed.), Mosby, London, 1968-1974 (2003).
Enlightened therapy of the disorders of cornification. Williams, ML, Elias, PM. Clin Dermatol. 21, 269-73 (2003).
Proksch, E, Jensen, JM, Elias, PM. Skin lipids and epidermal differentiation in atopic dermatitis. Clin Dermatol. 21, 134-44 (2003). http://www.ncbi.nlm.nih.gov/pubmed/12706331
Beyond glucocorticoids, retinoids and vitamin D – the evolution of nuclear hormone type transcription factor targeting in the skin. Schmuth, M., Elias, P.M., Feingold, K.R.J German Dermatol Soc. 1, 352-362 (2003).
The aged epidermal permeability barrier: basis for functional abnormalities. Elias, PM, Ghadially, R.Clin Geriatr Med. 18, 103-120 (2002).
The potential of metabolic interventions to enhance transdermal drug delivery. Elias, PM, Tsai, J, Menon, GK, Holleran, WM, Feingold, KR.J Investig Dermatol Symp Proc. 7, 79-85 (2002).
Stratum corneum pH: Formation and function of the ‘acid mantle’. Fluhr, JW, Elias, PM Exog Dermatol. 1, 163-175 (2002).
What is the ‘true’ function of skin? Chuong, CM, Nickoloff, BJ, Elias, PM, et al.Exp Dermatol. 11, 159-87 (2002).
Metabolic approach to transdermal drug delivery. Elias, P, Feingold, K, Tsai, J, Thornfeldt, C, Menon, G.In: Transdermal Drug Delivery. Guy, RH and Hadgraft, J (Ed.), Marcel Dekker, New York, 285-304 (2002).
Interference with stratum corneum lipid biogenesis: an approach to enhance transdermal drug delivery. Elias, P, Mak, V, Thornfeldt, C, Feingold, K In: Topical Absorption of Dermatological Products. Bronaugh, R and Maibach, H (Ed.), Marcel Dekker, New York, 261-274 (2002).
The skin and its barrier function: implications for wound healing. Elias, P, Wood, L, Feingold, K.In: Wound Healing and the Skin. Falanga, V (Ed.), Martin Dunitz, London, 5-14 (2001).
Skin of the premature infant.Williams, M. In: Textbook of Neonatal Dermatology. Eichenfield, LF, Frieden, IJ, and Esterly, NB (Ed.), W.B. Saunders, New York, 46-61 (2001).
Letter: importance of caution in prescribing topical tacrolimus (trade name Protopic®) for atopic dermatitis. Williams, M. Pediatr Notes. 25, 89-90 (2001).
Coordinate regulation of epidermal differentiation and barrier homeostasis. Elias, PM, Feingold, KR.Skin Pharmacol Appl Skin Physiol. 14 Suppl 1, 28-34 (2001).
Does the tail wag the dog? Role of the barrier in the pathogenesis of inflammatory dermatoses and therapeutic implications. Elias, PM, Feingold, KR. Arch Dermatol. 137, 1079-81 (2001).
Regulation of differentiation in newborn human keratinocytes by endogenous ligands of nuclear hormone receptors. Williams, M, Elias, P, Feingold, K.J Skin Barrier Res. 2, 3-21 (2000).
Notes to an aspiring dermatologist in the year 2000: inspired by Rainer Marie Rilke’s letters to a young poet. Elias, PM, Williams, ML. Arch Dermatol. 136, 37-40 (2000).
The epidermal barrier and strategies for surmounting it: an overview.Menon, G, Elias, P. In: The Skin and Gene Therapy. Hengge, U and Volc-Platzer, B (Ed.), Springer, New York, 1-26 (2000).
Ichthyosis: where we have been. Disorders of cornification: where we are going. Williams, M, Elias, P. Curr Probl Dermatol. 12, 170-176 (2000).