What Is EpiCeram®? EpiCeram® emulsion is a barrier-repair formulation, which is available by prescription only. It offers a unique, cortisone-free, topical therapy for patients with eczema and atopic dermatitis. EpiCeram® was developed based upon research from the Elias laboratory. Our research group has been concerned for many years with uncovering the means whereby skin prevents water from escaping out of the body – its permeability barrier. The Science Behind …LEARN MORE about The Story of EpiCeram®
WELCOME TO ELIAS & WILLIAMS
Are you curious about skin - how it works or what it does? Have you wondered why some people have strong and healthy skin, while other people’s skin is easily irritated and prone to rashes?
We, Peter M. Elias, M.D. and Mary L. Williams, M.D., are professors of dermatology and skin scientists who have spent our careers learning how the skin works in our laboratory and treating children and adults with skin disorders in our clinics. Here, we offer up to date and scientifically sound information about skin and how it works everyday – quietly and efficiently - to keep us well, and what is happening in our skin, when it is unwell.
We believe that, just as there is more to owning and operating a car then simply filling the gas tank and turning on the ignition, so, too, if we understand how the skin operates, this knowledge will make us better stewards of its health and beauty.
We provide both in-depth articles based upon the latest scientific understanding and research, as well as answers to some of the most commonly asked questions about skin. Whether you are just a curious person, or a parent with a child suffering from a skin disorder, or a practitioner in the skin-care industry, or a health care provider, we believe you will find here new and surprising information.
We offer our Special Report: Taking Good Care of Your Skin
This booklet offers up-to-date scientific information on how the skin works to keep us well and what we can do to maintain its health and beauty.Yes, Send Me the Guide
Skin’s Many Barriers And How Climate Change May Affect Them
Skin has many barriers: it keeps us waterproof, it holds back invading microorganisms, and it protects us from mechanical injury, from toxic rays of sunlight and foreign chemicals in our environment. Each of skin’s many barriers may be impacted as our environment changes as a result of global warming. To understand how skin will have to adapt to climate change we need to consider how these barrier’s work to keep us well.
The Skin’s Water Barrier Came First
Life on our planet began in its seas – a warm womb with a salinity that is close to that of a cell’s interior. But upon leaving the osmotic neutrality of the seas for life on land, our fish-like ancestors, the fishapods, suddenly would have encountered an entirely different world. There they faced a steep osmotic gradient between the much drier air outside and their water-based interior. They now required a water-proof covering to prevent the otherwise inevitable dehydration.
With that first step onto dry land – dawned a new evolutionary imperative, for them and for all their progeny who would follow. They required a means to prevent the loss of water from their cells into the arid atmosphere that now surrounded them.
Thus, before the grand experiment of terrestrial life could truly begin, this imperative – the need for a water barrier – had to be solved.
Indeed, all land dwelling species have had to evolve a water barrier on their external coverings (or ‘integuments’) – from the cuticles coating the leaves of plants, to the exoskeletons of insects, or to the scales of reptiles and to our human skin – in order to maintain their water-based way of life in a dry world.Read More…
INSIDE THE SKIN BARRIER
We hear a lot about the multitude and diversity the micro-organisms – especially the bacteria - that populate our stomach and intestines. We learn that these bugs living on and in us account for a …Read More...
REPAIRING THE SKIN BARRIER
An alarming percentage (about 60%) of normal adults, mostly women, self-report that they regularly experience ‘sensitive skin’. Most perceive ‘sensitive skin’ as various amounts of stinging, burning, …Read More...
Who is at risk? Many people are prone to develop dry skin. Examples include those who have or have in the past had atopic dermatitis. This is a common form of eczema that affects up to 20% of the …Read More...
CLIMATE AND THE SKIN
Q: COVID-19, climate change and skin? Are they related to each other, and if so how and why? A: Let's look first at COVID-19 and climate change, and see how they are and are not …Read More...
We have learned a lot about skin and its permeability barrier in recent years. Here are our picks for the top 5 discoveries about skin of the past decade. Some of these arose from work in …Read More...