Thoughts on the Rational Treatment of Atopic Dermatitis

This is the 4th in our series of updates on atopic dermatitis. In the preceding articles we considered why so many more children nowadays are developing eczema, what we know about the genetic underpinings of the disease, and how defects in the skin barrier and loss of the acidic pH on the skin surface are key to understanding how the dermatitis develops. In this post we consider how this information provides the basis for new, rational paradigms for treatment.

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Migration back to life on the farm is probably not an option for many, but there are steps that people with atopic dermatitis can take to address their skin’s vulnerability.  For a start, they can practice ‘gentle skin care’ and avoid extracting the natural oils from their skin that are essential for its barrier function by modifying their bathing routines. They can avoid long, hot showers; and instead maintain as-cool-as-is-comfortable water temperatures. And they should use a mild, and preferably acidic, cleanser – and use these judiciously, not excessively. After bathing, they should apply an ointment or cream that retains the moisture absorbed during bathing, and preferably replaces the barrier lipids that were removed, as well.  (For more information on how to take care of your skin, sign up to receive our free booklet: “Taking Good Care of Your Skin”)

The ideal formulation of a cream or ointment for the individual suffering from atopic dermatitis would both replace the normal lipids that were lost with bathing and also would correct the deficiencies in barrier lipids due to the disease itself, as well as restore an acidic pH and inactivate serine proteases. Thus, a corrective lipid replacement that is also formulated at a low pH, while also containing one or more ingredients that inhibit serine protease activity, would be whats needed for atopic dermatitis.  The only such product on the market is an the prescription product, Epiceram  emulsion. This product was developed based upon research from the Elias laboratory and is licensed by the University of California to PuraCap Pharma. Although there are many topical products on the market that make ‘barrier repair’ claims, Epiceram is the only product that has been shown to be effective even in moderate-to-severe atopic dermatitis, demonstrating the same anti-inflammatory efficacy as a mid-potency topical steroid. Importantly, Epiceram is safe, exhibiting none of the side effects of topical steroids, and it can be used on infants’ skin and on the face and body folds.

Mild flares of the dermatitis can be effectively managed with a corrective lipid replacement alone, while more rapid relief from more severe flares may benefit from the short-term addition of a topical corticosteroid, or in some instances, a topical immunosuppressant, like tacrolimus (Protopic) or pimecrolimus (Elidel).

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