Histamine and the Skin Barrier

Allergy Magazine January 2013Publication: Histamine suppresses epidermal keratinocyte differentiation and impairs skin barrier function in a human skin model.

Gschwandtner M, Mildner M, Mlitz V, Gruber F, Eckhart L, Werfel T, Gutzmer R, Elias PM, Tschachler E.  Allergy. 2013 Jan;68(1):37-47. Epub 2012 Nov 15.

Synopsis and Significance:  Histamine is another neurotransmitter, classically associated with allergic responses. We demonstrate here that it also binds to two receptors that are present in abundance in the outer part of skin, the epidermis. While it is known to mediate  itch arising deeper in the skin, in epidermis it decreases the production of critical proteins that form the cells of the stratum corneum.  In other words, histamine is ‘bad’ for the skin’s permeability barrier, and antihistamines can improve barrier function.

Copyright © 2013 Elias and Williams

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