Ceramides and Generation of the Skin’s Barrier

cover exper dermatolPublication: Ceramides stimulate caspase-14 expression in human keratinocytes.
Jiang YJ, Kim P, Uchida Y, Elias PM, Bikle DD, Grunfeld C, Feingold KR.
Exp Dermatol. 2013 Feb;22(2):113-8. doi: 10.1111/exd.12079.

Synopsis and Significance:

Ceramides are a key family of lipids, made by the epidermis, that are  required for the normal  function of the skin’s permeability barrier.  They also serve as cellular signals to trigger epidermal differentiation, resulting in formation of the permeability barrier.

Caspase 14 is an epidermal protease that regulates key events leading to barrier formation, including the breakdown of profilaggrin to filaggrin, a step in the formation of the corneocyte (or stratum corneum cell). Here, we identify a potential ‘feed-forward’ regulatory mechanism, whereby ceramides, destined for the lipid-based water barrier, also increase caspase-14 production and thereby enhance the formation of the cells that too are critical components of the skin’s barrier.

Copyright © 2013 Elias and Williams

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