Research from the Elias Lab

For nearly forty years, this University of California San Francisco-based research laboratory has focused on elucidating the structural and metabolic basis for the barrier function of the skin, including work aimed at understanding the cause and treatment of skin diseases.

The Seasons and the Skin Barrrier

It is common knowledge that many skin disorders, such as atopic dermatitis, get worse in the winter, but there is little agreement about the reasons for this phenomenon. Recently, a group of investigators in Australia observed that the severity of atopic dermatitis is related to latitude, and proposed that this could be the result of decreased vitamin D production from the weaker light at higher latitudes. We have suggested an alternate explanation for their findings: … [Read more...]

Urea: Much More Than A Mere Skin Moisturizer

Many ingredients in creams and ointments do more than just act locally on the skin surface or within the ‘stratum corneum’ (the outermost layers of skin). For example, urea is a compound that is widely used as a remedy for dry skin because of its ability both to hydrate or ‘moisturize’ the skin and to help remove skin build-up or scale. But urea also penetrates through the stratum corneum into the underlying nucleated cell layers of the epidermis. We have demonstrated … [Read more...]

Beyond Itch: Using Antihistamines to Treat Atopic Dermatitis and Psoriasis

Antihistamines to be taken by mouth – medications like Benadryl® and Atarax® - are commonly used to combat itch. Although they are very effective in the treatment of  itchy hives (‘urticaria’), all too often these drugs are not very successful in alleviating the itch of common, inflammatory skin disorders, such as ‘atopic dermatitis’ (eczema) or psoriasis. … [Read more...]

Copyright © 2013 Elias and Williams

Disclaimer: This website is for informational purposes only. Use of this website is not intended to substitute for professional medical judgment or advice. This website does not provide medical advice and nothing contained herein is intended to constitute professional advice for medical diagnosis or treatment.You should always consult a doctor regarding any skin care or medical problems or conditions. See our Terms of Use.