Press Room for Elias and Williams

Elias Delivers Dohi Memorial Lecture to Japanese Dermatology Association

On Saturday, June 15, 2013 Dr.  Peter Elias delivered the Dohi Memorial Lecture at the annual meeting of the Japanese Dermatological Association in Yokohama, Japan.  This invited lectureship is the highest honor accorded each year by the JDA.  The title of his presentation: "Treating Atopic Dermatitis at the Source: Correctve Barrier Repair Based upon New Pathogenic Insights." … [Read more...]

Elias Awarded Honorary Membership in Japanese Society

Following his invited lectureship on June 15, 2013,  Dr. Elias was awarded an honorary membership in the Japanese Dermatological Association at its 112th annual meeting. … [Read more...]

Featured in Allure May 2013 Issue

Our work on antihistamines and the skin also featured in the May 2013 issue of Allure magazine.  This work demonstrates that these commonly used drugs are applied directly to the skin they can improve the function of the skin barrier and also have potent anti-inflammatory effects.  This work holds promise for the development of new treatments for common skin disorders like atopic dermatitis and psoriasis. … [Read more...]

Our Research on Antihistimines and the Skin Barrier Featured on

A new treatment for common skin diseases like psoriasis and eczema (or atopic dermatitis), or other skin conditions with a defective skin barrier, is the hope raised by recent work from the Elias laboratory and featured in Allure this month.  These studies demonstrate that when antihistamines are applied topically to the skin, they improve the skin barrier.  This suggests that creams or ointments containing anithistamines of the type that do not cause sedation as a side effect could provide a … [Read more...]

Antihistamines and the Skin Barrier

Publication: Topical antihistamines display potent anti-inflammatory activity linked in part to enhanced permeability barrier function. Lin TK, Man MQ, Santiago JL, Park K, Roelandt T, Oda Y, Hupe M, Crumrine D, Lee HJ, Gschwandtner M, Thyssen JP, Trullas C, Tschachler E, Feingold KR, Elias PM. J Invest Dermatol. 2013 Feb;133(2):469-78. . Epub 2012 Sep 27. Synopsis and Significance: Usually, antihistamines are given by mouth to reduce itch.  Although they also have potent anti-inflammatory … [Read more...]

Histamine and the Skin Barrier

Publication: Histamine suppresses epidermal keratinocyte differentiation and impairs skin barrier function in a human skin model. Gschwandtner M, Mildner M, Mlitz V, Gruber F, Eckhart L, Werfel T, Gutzmer R, Elias PM, Tschachler E.  Allergy. 2013 Jan;68(1):37-47. Epub 2012 Nov 15. Synopsis and Significance:  Histamine is another neurotransmitter, classically associated with allergic responses. We demonstrate here that it also binds to two receptors that are present in abundance in the … [Read more...]

Evolution of Skin Pigmentation

Publication: Re-appraisal of current theories for the development and loss of epidermal pigmentation in hominins and modern humans. Elias PM, Williams ML. J Hum Evol. 2013 Mar 8. [Epub ahead of print] Synopsis and Significance: In this paper we propose that the evolution of dark skin pigmentation in human ancestors was driven by their need to preserve body water in the hot and dry climate of the equatorial African savannah. This, the most critical function of skin, is provided by the skin’s … [Read more...]

Ceramides and Generation of the Skin’s Barrier

Publication: Ceramides stimulate caspase-14 expression in human keratinocytes. Jiang YJ, Kim P, Uchida Y, Elias PM, Bikle DD, Grunfeld C, Feingold KR. Exp Dermatol. 2013 Feb;22(2):113-8. doi: 10.1111/exd.12079. Synopsis and Significance: Ceramides are a key family of lipids, made by the epidermis, that are  required for the normal  function of the skin's permeability barrier.  They also serve as cellular signals to trigger epidermal differentiation, resulting in formation of the … [Read more...]

Stress and Innate Immunity of the Skin

Publication: A novel role of a lipid species, sphingosine-1-phosphate, in epithelial innate immunity. Park K, Elias PM, Shin KO, Lee YM, Hupe M, Borkowski AW, Gallo RL, Saba J, Holleran WM, Uchida Y. Mol Cell Biol. 2013 Feb;33(4):752-62. Epub 2012 Dec 10. Synopsis and Significance: The antimicrobial peptide, LL-37, a cathelicidin, is a critical component of the skin's innate immune defense against infectious organisms. It's production by epidermal cells, 'keratinocytes', is known to be … [Read more...]

Skin Cancer and Atopic Dermatitis

Publication: Letter to the Editor in response to the commentary, 'Does a History of Eczema Predict a Future Basal Cell Carcinoma?' Elias PM, Williams ML.  J Invest Dermatol. 2013 Jan 22.  [Epub ahead of print] No abstract available.  PMID: 23340733 Synopsis and Significance:  Recently, a large Veterans Administration study showed an unexpected association between basal cell carcinoma, the most common ultraviolet-induced skin cancer, and a prior or current history of atopic dermatitis. In an … [Read more...]

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