Featured in Allure May 2013 Issue

Our work on antihistamines and the skin also featured in the May 2013 issue of Allure magazine.  This work demonstrates that these commonly used drugs are applied directly to the skin they can improve the function of the skin barrier and also have potent anti-inflammatory effects.  This work holds promise for the development of new treatments for common skin disorders like atopic dermatitis and psoriasis. … [Read more...]

Our Research on Antihistimines and the Skin Barrier Featured on Allure.com

A new treatment for common skin diseases like psoriasis and eczema (or atopic dermatitis), or other skin conditions with a defective skin barrier, is the hope raised by recent work from the Elias laboratory and featured in Allure this month.  These studies demonstrate that when antihistamines are applied topically to the skin, they improve the skin barrier.  This suggests that creams or ointments containing anithistamines of the type that do not cause sedation as a side effect could provide a … [Read more...]

Antihistamines and the Skin Barrier

Publication: Topical antihistamines display potent anti-inflammatory activity linked in part to enhanced permeability barrier function. Lin TK, Man MQ, Santiago JL, Park K, Roelandt T, Oda Y, Hupe M, Crumrine D, Lee HJ, Gschwandtner M, Thyssen JP, Trullas C, Tschachler E, Feingold KR, Elias PM. J Invest Dermatol. 2013 Feb;133(2):469-78. . Epub 2012 Sep 27. Synopsis and Significance: Usually, antihistamines are given by mouth to reduce itch.  Although they also have potent anti-inflammatory … [Read more...]

Histamine and the Skin Barrier

Publication: Histamine suppresses epidermal keratinocyte differentiation and impairs skin barrier function in a human skin model. Gschwandtner M, Mildner M, Mlitz V, Gruber F, Eckhart L, Werfel T, Gutzmer R, Elias PM, Tschachler E.  Allergy. 2013 Jan;68(1):37-47. Epub 2012 Nov 15. Synopsis and Significance:  Histamine is another neurotransmitter, classically associated with allergic responses. We demonstrate here that it also binds to two receptors that are present in abundance in the … [Read more...]

What Is the Best Lotion for My Dry Skin?

The best treatment for dry skin may not be a lotion at all.  Dry skin is the result of a problem with the stratum corneum and it’s ability to hold water within the tissue.  Many times this can be the result of a deficiency in the quantity or types of lipids (fats) that the skin employs to waterproof our bodies.  In the past it could be easily said that  lotions are mostly water and they would not deliver sufficient quantities of lipid to the skin to improve its waterproofing abilities.  These … [Read more...]

Ceramides and Generation of the Skin’s Barrier

Publication: Ceramides stimulate caspase-14 expression in human keratinocytes. Jiang YJ, Kim P, Uchida Y, Elias PM, Bikle DD, Grunfeld C, Feingold KR. Exp Dermatol. 2013 Feb;22(2):113-8. doi: 10.1111/exd.12079. Synopsis and Significance: Ceramides are a key family of lipids, made by the epidermis, that are  required for the normal  function of the skin's permeability barrier.  They also serve as cellular signals to trigger epidermal differentiation, resulting in formation of the … [Read more...]

Stress and Innate Immunity of the Skin

Publication: A novel role of a lipid species, sphingosine-1-phosphate, in epithelial innate immunity. Park K, Elias PM, Shin KO, Lee YM, Hupe M, Borkowski AW, Gallo RL, Saba J, Holleran WM, Uchida Y. Mol Cell Biol. 2013 Feb;33(4):752-62. Epub 2012 Dec 10. Synopsis and Significance: The antimicrobial peptide, LL-37, a cathelicidin, is a critical component of the skin's innate immune defense against infectious organisms. It's production by epidermal cells, 'keratinocytes', is known to be … [Read more...]

Neurotransmitters and the Skin Barrier

Publication: Cannabinoid receptors 1 and 2 oppositely regulate epidermal permeability barrier status and differentiation. Roelandt T, Heughebaert C, Bredif S, Giddelo C, Baudouin C, Msika P, Roseeuw D, Uchida Y, Elias PM, Hachem JP. Exp Dermatol. 2012 Sep;21(9):688-93. Synopsis and Significance:  Both the outer part of skin, the epidermis, and  the brain  derive from the epithelial layer that covers the outside of the  embryo during early fetal life. Likely because of this common origin, the … [Read more...]

The Seasons and the Skin Barrrier

It is common knowledge that many skin disorders, such as atopic dermatitis, get worse in the winter, but there is little agreement about the reasons for this phenomenon. Recently, a group of investigators in Australia observed that the severity of atopic dermatitis is related to latitude, and proposed that this could be the result of decreased vitamin D production from the weaker light at higher latitudes. We have suggested an alternate explanation for their findings: … [Read more...]

Inflammation May Help Fix the Skin Barrier in Psoriasis (But Not in Atopic Dermatitis)

Both psoriasis and atopic dermatitis are considered multigenic disorders, meaning an inherited predisposition to develop one of these is carried on more than one gene. In addition to bad genetic luck, usually some environmental (or non-genetic) factor(s) is necessary to trigger the disease. In recent years, studies of populations have determined that variations (‘polymorphisms’) in genes that are involved in the skin barrier as well as genes of the immune system are linked to the development of … [Read more...]

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